Table 4 Selected gene ontology biological processes significantly enriched among genes within 50Â kb of a BRG1- associating site and GLI consensus binding motifa
Category | Targets | Hypergeometric | Example genes |
|---|---|---|---|
P-value | |||
Regulation of gene expression | 501 | 3.35E-25 | Atf2, Meis1, Ncoa2, Ncor1, Smad2 |
Cellular process | 1211 | 4.15E-25 | Actn1, Ctnna1, Ctnnd1, Mapt, Myo1e |
System development | 418 | 1.04E-22 | Angpt1, Fgf15, Fgf18, Pdgfa |
Cell differentiation | 342 | 2.50E-20 | Creb1, Dhh, Mef2d, Ptch1, Rara, Smo |
Nervous system development | 235 | 6.98E-17 | Bdnf, Neurod4, Nkx2-2, Pax6 |
Pattern specification process | 77 | 4.21E-10 | Hoxa2, Hoxa9, Hoxd3, Yy1 |
Ear morphogenesis | 25 | 3.67E-09 | Atoh1, Otx1, Otx2, Gata2 |
Heart development | 69 | 5.55E-09 | Foxh1, Notch1, Tbx20, Ttn, Wnt5a |
Regulation of cell cycle | 99 | 4.45E-07 | Cdc26, Cdk4, Cdk6, E2f1, E2f2 |
Osteoblast differentiation | 20 | 7.13E-06 | Bmp2, Gli1, Gli2 |
Cell migration | 79 | 1.05E-05 | Epha2, Fat1, Lama5, Lamc1, Tubb2b |
Chromosome organization | 108 | 4.83E-05 | Hdac3, Mll3, Myst2, Smarca2, Smarcd1 |