Fig. 5
From: Late stage definitive endodermal differentiation can be defined by Daf1 expression
Proposed role of Daf1 in DE differentiation. ICM/ESC differentiated into the E-cadherin + Cxcr4 + Foxa2 + Sox17lowDaf1- early DE. These cells then differentiated into the E-cadherin + Cxcr4 + Foxa2 + SOX17highDaf1+ late DE. The late DE differentiated into regionalized anterior (pancreatic) and posterior (intestinal) endodermal lineages. Transition from the Daf1-DE to Daf1 + DE is accompanied by restricted cell proliferation and cell-matrix adhesion. ICM; inner cell mass