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Fig. 8 | BMC Developmental Biology

Fig. 8

From: β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis

Fig. 8

ad Immunostaining for β-CATENIN (green) on e11.5 sagittal sections, counterstained with DAPI (blue). a and b Wild type embryo. Arrow in a indicates the level of the infundibulum. Boxed region is magnified in b. c and d Wnt1-cre; β-cat fx/fx embryo. Arrow in c indicates the level of the infundibulum. Boxed region is magnified in d. Arrow in d indicates cells at the posterior diencephalon and midbrain boarder deficient for β-CATENIN. eh Immunostaining for OTX2 (green) on e11.5 sagittal sections, counterstained with DAPI (blue). e and f Wild type embryo. Arrow in e indicates the level of the infundibulum. Boxed region is magnified in f. Arrow in f indicates a low level of OTX2 expression. g and h Wnt1-cre; β-cat fx/fx embryo. Arrow in g indicates the level of the infundibulum. Boxed region is magnified in h. Arrow in h indicates a low level of OTX2 expression. il Immunostaining for LEF1 (green) on e11.5 sagittal sections, counterstained with DAPI (blue). (i and j) Wild type embryo. Arrow in i indicates the level of the infundibulum. Boxed region is magnified in j. Arrow in j indicates the boundary of LEF1 expression. k and L Wnt1-cre; β-cat fx/fx embryo. Arrow in k indicates the level of the infundibulum. Boxed region is magnified in l. Arrow in L indicates the boundary of LEF1 expression. All scale bars equal 100 μm

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