Skip to main content
Fig 5 | BMC Developmental Biology

Fig 5

From: Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development

Fig 5

Examples of network structure rearrangements during the perinatal transition. Illustrative examples of the internal structure of the regulatory reorganization in three representative modules. Each module or gene cluster is represented as a graph of coexpression relationships, where nodes represent genes and edges represent high correlations (R > 0.95) between pairs of genes. Red edges represent prenatal-only high correlations, blue edges represent postnatal-only high correlations and black edges represent constant (prenatal and postnatal) high correlations. a Module M15 shows an almost exclusive transition from high to low correlation in all involved genes in the transition from prenatal to postnatal development. By contrast module M7 b shows a transition from high to low coordination between genes in a subnetwork with a simultaneous transition from low to high correlated activity in a second sub-network. Module M5 c shows an almost exclusive transition from low to high correlation in all genes involved during the transition from prenatal to postnatal brain development. Inset: bar plots showing the mean number of prenatal (red) or postnatal (blue) edges per node (degree) in each module

Back to article page