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Fig 4 | BMC Developmental Biology

Fig 4

From: Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development

Fig 4

Regulatory reorganization modules are enriched in defined sets of biological processes and targeted by specific sets of transcription factors. a Bar plot showing the number of significantly enriched GO terms per individual module. Statistical significance in enrichment of surveyed biological process GO terms (n = 106) was determined by means of a Z-score test, where the expected number of genes annotated to individual GO terms was determined numerically by comparing with 10 000 equally sized random samples of genes. Significance threshold was adjusted for multiple testing by Benjamini Hochberg correction (FDR < 0.05). b Bar plot showing the number of significantly enriched of transcription factor target motifs per individual reorganization module using Webgestalt’s transcription factor target (TF) enrichment toolkit. c Venn-Euler diagram showing the relative number of TF binding motifs statistically overrepresented within each individual module. The area of each circle represents the number of enriched TF binding sites in each module and the overlap represents the relative proportion of overlapping motifs between modules. Note that each module targets a quasi-exclusive set of biological functions with rare overlap between modules

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