Fig 3

Differential coexpression network dendrogram and gene modules. a Dendrogram showing average hierarchical clustering based on the topological overlap of the adjacency matrix based on coexpression differences (see methods) and the corresponding gene modules indicated in different colours underneath. b Histogram showing cluster size (number of genes) per module. c Heat maps of the Pearson correlation coefficients between all possible gene pairs contained within each module. Each heat map shows prenatal and postnatal coexpression separately (upper and lower diagonal respectively). Colour scale for correlation coefficients is shown at the top left corner of this panel. Modules are arranged from left to right and top to bottom according to the median correlation difference between prenatal and postnatal stage. d Graph showing the change in the average correlation of each module between pre and postnatal stages. Each arrow represents the difference in postnatal average correlation relative to the prenatal stage. 17 out of 23 differentially coexpressed modules displayed increased correlated expression in the postnatal stage with six modules showing reduced correlated activity in transition from pre to postnatal development