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Fig 1 | BMC Developmental Biology

Fig 1

From: Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development

Fig 1

Developmental stage, but not anatomical structure contributes to the greatest component of variance in gene expression profiles. Principal component analysis splitting samples of expression data by either a structure, b post conception age or c prenatal/postnatal stage. Each plot shows the first and second components (together contributing to 68.83% of variance). Kruskal-Wallis test was carried out on PC1 to test for associations between this component and either, structure, post conception age or prenatal/postnatal stage. Associated p values are indicated. d Relatedness between average postnatal or prenatal expression profiles across anatomical regions. Average expression per gene per cortical region was obtained for either prenatal or postnatal samples across all analysed cortical regions. Unsupervised hierarchical clustering was conducted using pairwise correlations between all resulting average expression profiles as a measure of similarity. Note, that the average expression profiles of any two prenatal regions are mores similar to each other, than they are to themselves across the perinatal boundary. Acronyms for brain structures: Dorsolateral prefrontal cortex (DFC), Posteroinferior parietal cortex (IPC), Medial prefrontal cortex (MFC), Orbital frontal cortex (OFC), Primary somatosensory cortex (S1C), Posterior superior temporal cortex (STC), Primary visual cortex (V1C) and Ventrolateral prefrontal cortex (VFC)

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