Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis

Chung-Davidson, Yu-Wen; Yeh, Chu-Yin; Bussy, Ugo; Li, Ke; Davidson, Peter J.; Nanlohy, Kaben G.; Brown, C. Titus; Whyard, Steven; Li, Weiming

doi:10.1186/s12861-015-0097-2

BMC Developmental Biology

Table 1 Transporter gene expression at various metamorphic stages

From: Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis

Transporters	Transported molecules	L	M2	M5	JV
abca1	Cholesterol	+	+	+	+
abcb4	Phosphotidylcholine (hepatocyte to bile)		+	++
abcb6	Unknown (Half transporter, mitochondrial)		++	+
abcb9	Unknown (Half transporter, lysosomal)			+	++
abcc5	Cyclic nucleotide			+	++
abcd2	Fatty acid, fatty acyl-CoA (Half transporter, peroxisomal)				++
abcg2	Xenobiotic		+	++
atp1a2	Na⁺/K⁺		+	++	++
atp1b3	Na⁺/K⁺		+	++	+++
atp2a1	Ca²⁺ (cytosol to ER)	+	++
atp2a2	Ca²⁺(cytosol to ER)	++	+
atp2b1	Ca²⁺ (Plasma membrane)			+	++
atp5j2	H⁺ (Mitochondrial)		+	++
atp5o	H⁺ (Mitochondrial)	+	++		++
atp6v1f	H⁺ (Mitochondrial)	+	++
atp6v1h	H⁺ (Mitochondrial)	+	++
atp8a1	Aminophospholipid (phosphotidyl serine)		++	+
atp10d	Phospholipid	++	+	++
slc1a1	Glu		+	++
slc2a9	Glucose		++	+
slc4a4	Na⁺, bicarbonate	++	+
slc4a11	Na⁺, borate	++	+	++	++
slc5a6	Na⁺, vitamin (pentothenate, biotin, lipoate)	+	++	+	+++
slc5a7	Na⁺, Cl^-/Choline	+	++	+
slc6a2	Na⁺, NE			+	++
slc6a6	Na⁺/taurine, β-Ala	+	++	+
slc6a8	Creatine			+	++
slc6a12	GABA, betaine	++	+	++	+++
slc7a1	Cationic amino acid				++
slc7a5	Cationic amino acid	++	+	++
slc7a6	Na⁺/cationic amino acid	++	+	++
slc7a8	Neutral amino acid	+	++	+
slc7a11	Cationic amino acid	++	+	++	++
slc9a7	Na⁺/H⁺	+	++	+	+++
slc10a1	Na⁺, bile acids (basal)	++	++	+++	++++
slc12a2	Na⁺/K⁺/Cl^-	++	+
slc12a6	K⁺, Cl^-	++	+	++	+++
slc15a1	H⁺/peptide	++	+	++
slc15a2	H⁺/peptide	++	+	++
slc16a4	H⁺/monocarbohydrates	+	++	++	+++
slc18a2	Monoamine (vesicular)	++	+
slc19a2	Thiamine	+	++
slc20a1	Na⁺, phosphate	+	++
slc20a2	Na⁺, phosphate	+	++	+++	+++
slc22a3	Organic cations	+	++	+	++
slc22a18	Organic cations	+	++
slc23a1	Vitamin C	+	++	+
slc23a2	Vitamin C	+	++	+
slc25a1	Citrate-H⁺, malate (Mitochondrial)	+	++	++	+++
slc25a3	Phosphate (cytosol to mitochondrial)		+	++
slc25a5	ADP (mitochondrial to cytosol)		+	++
slc25a13	H⁺/Asp, Glu (mitochondrial)		+	++
slc25a26	Metabolites, cofactors (mitochondrial)				++
slc25a36	Unknown				++
slc26a5	Cl^-, bicarbonate	+	++
slc27a6	Fatty acid	++	+
slc29a1	Nucleoside				++
slc30a1	Zn²⁺				++
slc30a2	Zn²⁺	++++	+++	++	++
slc35a3	UDP-GlcNac	++	+
slc35b1	UDP-galactose	+	++	+
slc35b2	3′-phospho-5′-phosphosulfate	+	++
slc35b4	UDP-xylose, UDP-GlcNAc	+	++
slc37a4	Glucose-6-phosphate			+	++

L larva, M2 metamorphic stage 2, M5 metamorphic stage 5, JV newly transformed juvenile, + expressed with at least 2-fold difference between paired transcriptomes

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