Fig. 3
From: The developmental basis of mesenchymal stem/stromal cells (MSCs)
Comparison of MSC-related phenomena in vivo and in vitro. In vivo, progenitor populations that will give rise to the adipocyte, chondrocyte and osteoblast lineages pass through developmental phases that progressively restrict their fate choices. This is correlated with progressively limited differentiation potentials of corresponding stem cell populations cultured in vitro. ICM: inner cell mass; ESCs: embryonic stem cells; Epi-SCs: epiblast stem cells; LPM: latral plate mesoderm; MSCs: mesenchymal stem cells. Corresponding stem cell populations for the mesoderm (pan-mesoderm stem cells) and LPM (pan-lateral plate mesoderm stem cells) have not yet been reported