Fig. 9
From: Meis2 is essential for cranial and cardiac neural crest development
Expression of neural crest cell specifier genes FoxD3 and Sox9 in the absence of Meis2. (a-a’) In situ hybridization of FoxD3 on E9.5 Meis2-/- embryos and controls with an abnormal position of migrating NCC in the midline of the midbrain, hindbrain and spinal cord (arrows in side and dorsal views in a’). (b-b’) Sox9 mRNA staining at E9.5 with ectopic cells in the midline (arrows in side and dorsal views in (a’) and smaller otic vesicles (arrowheads) in systemic mutants. (c-c’) In situ hybridization of neural crest cell specifier mRNA FoxD3 and Sox9 (d-d’) in conditional AP2α-Cre/Meis2cKO at E9.5. Side and corresponding dorsal view magnifications illustrate no change in their expression in conditional mutants