Fig. 6
From: Meis2 is essential for cranial and cardiac neural crest development
The absence of Meis2 leads to perturbed development of cranial nerves. (a-a’) Neurofilament staining using 2H3 antibody revealed absent or abnormally positioned cranial nerves trigeminal V, facial VII and vestibulocochlear VIII in Meis2-/-. (b-b’) A detail of the framed areas in (a) showing severed nerves V, VII (asterisks). (c-c’) Lineage tracing of NCC in AP2α-Cre /Meis2 cKO/ROSA26 embryos at E10.5 and controls. Transverse head sections in the eye area. (d-d’) Neurofilament 2H3 staining of cKO embryos at E10.5 with impaired nerves VII and VIII (asterisks). (e-e’) Hematoxylin-eosin staining of the eye from cKO at E17 shows shrunken eyelids (el) and cornea (arrow). Cranial nerves III, V, VII, VIII, X; el, eye lid; oc, optic cup; pm, periocular mesenchyme