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Fig. 2 | BMC Developmental Biology

Fig. 2

From: Meis2 is essential for cranial and cardiac neural crest development

Fig. 2

Mapping of Meis2 expression in the mouse embryo at E13. Meis2 protein is present in many developing tissues including the forebrain, midbrain, hindbrain, spinal cord, myocardium, cardiac cushions, cardiac outflow tract, valves (aortic, pulmonary, tricuspid, mitral). (a) A sagittal section of the whole embryo with a detail of the heart (A’) documenting Meis2 presence in the myocardium (arrow) and pericardium (arrowhead). (b-e) Transverse sections of the heart at E13 from rostral to caudal with details of the framed areas (b’-e’) illustrating strong Meis2 expression in cardiac valves. (f) Immunofluorescent labeling of sarcomeric actin in the wild-type heart at E13. (f’-f”) Double labeling of sarcomeric actin (red) and Meis2 (green), a higher magnification view on the framed area in (f) showing Meis2 in the myocardium (arrows) and in the atrioventricular cushion. ao, aorta; av, aortic valve;, pv, pulmonary valve; mv, mitral valve; avc, atrioventricular cushion

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