TY - JOUR AU - Machon, Ondrej AU - Masek, Jan AU - Machonova, Olga AU - Krauss, Stefan AU - Kozmik, Zbynek PY - 2015 DA - 2015/11/06 TI - Meis2 is essential for cranial and cardiac neural crest development JO - BMC Developmental Biology SP - 40 VL - 15 IS - 1 AB - TALE-class homeodomain transcription factors Meis and Pbx play important roles in formation of the embryonic brain, eye, heart, cartilage or hematopoiesis. Loss-of-function studies of Pbx1, 2 and 3 and Meis1 documented specific functions in embryogenesis, however, functional studies of Meis2 in mouse are still missing. We have generated a conditional allele of Meis2 in mice and shown that systemic inactivation of the Meis2 gene results in lethality by the embryonic day 14 that is accompanied with hemorrhaging. SN - 1471-213X UR - https://doi.org/10.1186/s12861-015-0093-6 DO - 10.1186/s12861-015-0093-6 ID - Machon2015 ER -