Table 3 Cardiac function as assessed by M-mode echocardiography in wild type versus Mbnl1 ∆E3/∆E3 hearts
From: Muscleblind-like 1 is required for normal heart valve development in vivo
|  | Wild type male (n = 8) | Mbnl1 ∆E3/∆E3 male (n = 7) | P value | Wild type female (n = 5) | Mbnl1 ∆E3/∆E3 female (n = 7) | P value |
|---|---|---|---|---|---|---|
Heart rate (beats/min) | 491.6 ± 21.7 | 512.7 ± 22.2 | 0.25 | 482.2 ± 38.7 | 488.7 ± 21.2 | 0.44 |
Anterior wall thickness, diastole (mm) | 0.43 ± 0.02 | 0.48 ± 0.02 | 0.04* | 0.43 ± 0.02 | 0.49 ± 0.03 | 0.03* |
Anterior wall thickness, systole (mm) | 0.57 ± 0.03 | 0.60 ± 0.02 | 0.18 | 0.53 ± 0.03 | 0.54 ± 0.02 | 0.40 |
LV diameter, diastole (mm) | 3.96 ± 0.16 | 4.17 ± 0.16 | 0.18 | 3.79 ± 0.10 | 3.70 ± 0.06 | 0.25 |
LV diameter, systole (mm) | 2.43 ± 0.13 | 2.75 ± 0.22 | 0.12 | 2.31 ± 0.15 | 2.38 ± 0.06 | 0.33 |
LV posterior wall thickness, diastole (mm) | 0.52 ± 0.02 | 0.52 ± 0.03 | 0.49 | 0.46 ± 0.02 | 0.55 ± 0.03 | 0.03* |
LV posterior wall thickness, systole (mm) | 0.56 ± 0.02 | 0.58 ± 0.04 | 0.31 | 0.53 ± 0.01 | 0.55 ± 0.01 | 0.19 |
Ejection fraction (%) | 75.3 ± 1.8 | 69.4 ± 4.1 | 0.11 | 75.8 ± 2.8 | 72.1 ± 1.2 | 0.14 |
Fractional shortening (%) | 38.6 ± 1.6 | 34.7 ± 3.4 | 0.16 | 39.4 ± 2.4 | 35.9 ± 1.0 | 0.11 |