Conservation analysis of sequences flanking the testis-determining gene Sry in 17 mammalian species

Table 2 Enriched motifs identified by CentriMo and FIMO

Figure 6 Label	Motif DB	Motif ID	E-value	Position relative to anchor SP motif
Panel A
Oct	Jolma	POU3F4_DBD	2x10⁻⁶	−443
MafK	Jolma	MAFK_full	0.5	−435
Sox	JASPAR	MA087.1	10⁻³	−234
Tcf, Lef	UniPROBE	UP00054_1	5x10⁻⁴	−197
NR4A2	JASPAR	MA0160.1	6	−169
Pitx, Dmbx, Gsc	Jolma	PITX3_DBD	0.3	−142
Rhox, Dprx	Jolma	RHOXF1_DBD_2	0.03	−127
Oct/Sox, Pbx	JASPAR	MA0142.1	10⁻⁶	−66
NFI	JASPAR	MA0119.1	3x10⁻⁶	−36
Tfap	Jolma	TFAP2C_full	3x10⁻⁶	−30
Gcm, Sox, Rar	UniPROBE	UP00048_2	3x10⁻³	−24
Pbx, Esrr	UniPROBE	UP00079_2	0.8	−18
SP, Egr, Smad, Klf, Zfp, Gli, Gabpa, Insm, Mzf, Zic	UniPROBE	UP00007_2	3x10⁻¹⁰	−12
NR2E1	Jolma	NR2E1_full	0.4	+33
Panel B
Dobox	UniPROBE	UP00232_1	1	−4976
NR2F6	Jolma	NR2F6_DBD_2	0.03	−760
Evx, Gata	Jolma	EVX1_DBD	0.01	−293

Details of the motifs depicted in Fig. 6. The first column corresponds to the labels used, from left to right, in Fig. 6. The next two columns refer to the specific motif id, and its containing database, that provides the smallest E-value for motifs at or around that particular site within the sequence (subject to the additional constraint that included motifs must also be present in at least 8 species). The final column reports an E-value (to 1 significant figure) for each of the motifs. Although this table reports a single motif at each site, redundancy of databases and similarity of binding sites for multiple transcription factors means that multiple motifs are typically found to be enriched at each of these sites. Full results can be found in Additional file 8 for Panel A, and Additional file 10 for Panel B

ISSN: 1471-213X