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Fig. 1 | BMC Developmental Biology

Fig. 1

From: The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model

Fig. 1

Quantitative PCR of Tbx5 mRNA levels in pooled E11.5 hearts. mRNA expression was reduced to almost 10 % of wild type levels in Tbx5 +/− mice (p = 0.004). Note that previous studies found expression levels reduced to 20 % of wild type levels in E8.5 Tbx5 +/− embryos on a mixed Black Swiss/129 background [21]. We found expression was also reduced to 30 % of wild type levels in Ts65Dn mice (p = 0.01), and 2 % of wild type levels in Ts65Dn;Tbx5 +/− hearts (p < 0.001). Error bars are standard deviation from the mean

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BMC Developmental Biology

ISSN: 1471-213X

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