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Fig. 4 | BMC Developmental Biology

Fig. 4

From: Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development

Fig. 4

Safranin-Weigert staining of Hox mutant limbs. Arrowhead: radius, Arrow: ulna. ad, E14.5. a: Wild type, note resting chondrocytes near ends, the proliferative zone more medial, and the hypertrophic compartment, with white spaces. b: Hoxa9,10,11 −/−;Hoxd9,10,11 +/−, shorter and thicker radius and ulna. c: Hoxa9,10,11 +/−;Hoxd9,10,11 −/−, shorter and thicker radius and ulna. d: Hoxa9,10,11 −/−;Hoxd9,10,11 −/−, nearly absent radius and ulna, with only resting chondrocyte morphology. e and f, E15.5. e: Hoxa9,10,11 −/−;Hoxd9,10,11 +/−, cells present in outgrowth of radius are rotated 90° (insert). f: Hoxd9,10,11 +/-, normal cell orientation and differentiation compartments (insert)

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