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Fig. 2 | BMC Developmental Biology

Fig. 2

From: Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development

Fig. 2

Altered Shh and Fgf8 expression in E10.5 Hoxa9,10,11/Hoxd9,10,11 mutants. ae: Shh expression in the ZPA. a: Wild type. b: Hoxa9,10,11 −/−;Hoxd9,10,11 +/−, reduced expression level. c: Hoxa9,10,11 −/−, normal expression. d: Hoxa9,10,11 +/−;Hoxd9,10,11 −/−, decreased expression. e: Hoxa9,10,11 −/−;Hoxd9,10,11 −/−, nearly absent expression, arrowhead pointing to ZPA. fj: Fgf8 expression in the AER. f: Wild type. g: Hoxa9,10,11 −/−;Hoxd9,10,11 +/−, reduced anterior expression. h: Hoxa9,10,11 −/−, normal expression. i: Hoxa9,10,11 +/−;Hoxd9,10,11 −/− reduced and patchy expression. j: Hoxa9,10,11 −/−;Hoxd9,10,11 −/−, Decreased expression, arrowhead pointing to anterior edge of the AER, where expression was most severely reduced

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