Fig. 2

Altered Shh and Fgf8 expression in E10.5 Hoxa9,10,11/Hoxd9,10,11 mutants. a–e: Shh expression in the ZPA. a: Wild type. b: Hoxa9,10,11 ^−/−;Hoxd9,10,11 ^+/−, reduced expression level. c: Hoxa9,10,11 ^−/−, normal expression. d: Hoxa9,10,11 ^+/−;Hoxd9,10,11 ^−/−, decreased expression. e: Hoxa9,10,11 ^−/−;Hoxd9,10,11 ^−/−, nearly absent expression, arrowhead pointing to ZPA. f–j: Fgf8 expression in the AER. f: Wild type. g: Hoxa9,10,11 ^−/−;Hoxd9,10,11 ^+/−, reduced anterior expression. h: Hoxa9,10,11 ^−/−, normal expression. i: Hoxa9,10,11 ^+/−;Hoxd9,10,11 ^−/− reduced and patchy expression. j: Hoxa9,10,11 ^−/−;Hoxd9,10,11 ^−/−, Decreased expression, arrowhead pointing to anterior edge of the AER, where expression was most severely reduced