Skip to main content
Fig. 1 | BMC Developmental Biology

Fig. 1

From: Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development

Fig. 1

Limb malformations in mice with mutations of Hoxa9,10,11 and Hoxd9,10,11. ak: Alcian blue (cartilage) and Alizarin red [52] staining of E18.5 limbs. ag Forelimb a: wild type, note size of radius, ulna, humerus, and deltoid process. b: Hoxa9,10,11 −/−, thickening of the radius and ulna. c: Hoxa9,10,11 −/−;Hoxd9,10,11 +/−, thickening and shortening of the radius and ulna, slight outgrowth of the radius. d: Hoxa9,10,11 +/−;Hoxd9,10,11 +/−, comparable to wild type in size and shape. e: Hoxd9,10,11 −/−, thin humerus, and absent deltoid process. f: Hoxa9,10,11 +/−;Hoxd9,10,11 −/−, absent deltoid process, severe shortening of the radius and ulna, large outgrowth on the radius. g: Hoxa9,10,11 −/−;Hoxd9,10,11 −/− absent deltoid process, near absence of the radius and ulna, syndactyly of digits 2 and 3. hk Hindlimb h: Wild type, note size and separation of tibia, fibula, and tarsals. i: Hoxa9,10,11 −/−;Hoxd9,10,11 −/−, Complete distal separation and thickening of the tibia and fibula. j: Hoxa9,10,11 +/−; Hoxd9,10,11 −/−, thickening of the tibia and fibula. k: Hoxa9,10,11 −/−;Hoxd9,10,11 −/−, Shortening, thickening, and separation of the tibia and fibula, absence of tarsal. lo: In situ hybridization of E11.5 forelimb bud. lm Hoxd12 in situ probe. l: wild type. m: Hoxa9,10,11 −/−;Hoxd9,10,11 −/−. no Hoxd13 in situ probe. n: wild type. o: Hoxa9,10,11 −/−;Hoxd9,10,11 −/−. Note similar expression levels in mutants

Back to article page