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Fig. 1 | BMC Developmental Biology

Fig. 1

From: FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice

Fig. 1

Comparison of postnatal weight-growth curves and IGF1/GH axis gene expression in WT and Foxl2 −/− mice. (a) Growth curves of WT and Foxl2 −/− show significant differences in body weight starting at P21-23, indicated by a dotted line (p value ≤ 0.0001, determined by Student’s T test). (b,c) Growth rates show the different trends between P10 and P30 (shaded area): decline is greater in Foxl2 −/− than in WT with delay of the subsequent growth spurt. (d) RT-qPCR in Foxl2 −/− mice at P7 shows increased expression of Ghrh in hypothalamus, (e) reduced expression of both Ghrhr and Gh in pituitary gland, and (f) reduced expression of Igf1 in skull vault and liver

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