Fig. 5

Effect of RNAi-mediated Myc silencing on glial dedifferentiation and programmed cell death. a Relative area occupied by fully differentiated radial glial cells within 1 mm from the wound in control animals injected with the vehicle or an irrelevant (GFP-targeting) DsiRNA (GFP Dsi) and in animals injected with Myc-targeting DsiRNAs (Myc Dsi1 and Myc Dsi2). Day 2 post-injury/DsiRNA injection. b Relative abundance of TUNEL-positive cells in the radial nerve cord within 1mm from the wound on day 2 post injury/DsiRNA injection. The control animals were injected either with the vehicle or with an irrelevant DsiRNA (GFP Dsi). The Myc-targeting DsiRNAs are designated as Myc Dsi1 and Myc Dsi2. The data are plotted as mean ± standard error. * p<0.05, ** p<0.01, *** p<0.001