Figure 7
From: The medaka dhc2 mutant reveals conserved and distinct mechanisms of Hedgehog signaling in teleosts
Proposed model of the distinct features of Hh signal transduction in insect, fish and mammal. fu is expressed in a Hedgehog-dependent fashion and is also one of the components of the Hedgehog pathway in fish. Fused negatively regulates Suppressor of Fused (SuFu), which is a negative regulator of Gli/Ci in Hh signaling. The transcription of fused in fish could lead to Hh activation. This positive-feedback loop amplifies Hedgehog pathway in fish downstream of cilia.