Figure 7
From: Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophilamale accessory gland cells
Model for binucleation and isoform-specific functions of Mud. Schematic diagrams of cell division and binucleation are shown. In binucleation, MudS changes mitosis from cell division to binucleation by (1) reorienting the mitotic spindle from horizontal to vertical along the apico-basal axis and (2) repressing assembly of the central spindle. MudPBD is also required at this time for orienting the spindle along the apico-basal axis. MudL, in contrast, (3) represses mitotic cell rounding and may assist in the process of cytokinesis skipping by (4) partially repressing the assembly of the central spindle.