Figure 4
From: Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
SDF-1 and its receptor CXCR4 are expressed in developing mouse pancreas and SMG. Pancreatic (A-D) and SMG (E-H) sections at e12.5 (A, B, E and F) and e14.5 (C, D, G and H) were processed for in situ hybridizations using antisense probes for SDF-1 and for CXCR4. SDF-1 is expressed in the mesenchyme and its receptor in epithelial cells (pancreatic epithelium is delineated by a dotted line). At e14.5, SDF-1 staining is also found in pancreatic epithelial cells. Capillaries are positive for both the ligand and receptor (arrows). Scale bars, 100 μm (A-D); 200 μm (E-H).