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Figure 2 | BMC Developmental Biology

Figure 2

From: Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1levels during early mouse development

Figure 2

The cax mutation is an allele of Pofut1. (A) Genetic map position of chromosome 2 around the cax mutation based on analysis of 1339 backcross progeny. Markers and genetic distances are indicated below and above the map, respectively. (B) Physical map of the Pofut1 genomic region and location of D2Mit195. (C) Normal external (a) and skeletal (b) phenotype of E15.5 heterozygous cax/+ mice, and shortened body axis (c) and defective axial skeleton (d) in Pofut1tm1Pst/caxdouble heterozygous mice. (D) Reduced levels of Pofut1 mRNA in Pofut1cax/caxmutants (b, d) compared with wild type embryos (a, c) on E9 (a, b) and E9.5 (c, d) detected by in situ hybridization under identical hybridization and staining conditions. Red lines in c and d indicate the PSM and somites.

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