Down-regulated | Embryonic Stem Cell Array | Day 4 Embryoid Body Array | |||||||
---|---|---|---|---|---|---|---|---|---|
Gene ID | Gene Description | RefSeq | Chr | ES Array Fold Change | Q-PCR data Fold Change | P-value | EB Array Fold Change | Q-PCR data Fold Change | P-value |
Tgf-beta pathway | |||||||||
Id1 | Inhibitor of DNA binding 1 | NM_010495 | 2 | 9.2 | 8.43 ± 2.09 | 0.013 | 7.4 | 23.3 ± 4.14 | 0.0017 |
Id2 | Inhibitor of DNA binding 2 | NM_010496 | 12 | 3.8 | 7.23 ± 2.32 | 0.1193 | 1.7 | n.d. | n.d. |
Id3 | Inhibitor of DNA binding 3 | NM_008321 | 4 | 2.8 | 3.13 ± 0.72 | 0.0279 | 1.8 | n.d. | n.d. |
Gdf1 | Growth differentiation factor 1 | NM_008107 | 8 | 4.0 | 3.73 ± 0.18 | <0.0001 | 1.75 | 4.01 ± 0.56 | 0.0018 |
Lefty2 (Ebaf) | Left-right determination factor 2 | NM_177099 | 1 | 3.7 | 5.47 ± 1.18 | 0.0096 | 1.47 | n.d. | n.d. |
Lefty1 | Left-right determination factor 1 | NM_010094 | 1 | 1.6 | 1.77 ± 0.1 | 0.0004 | - | n.d. | n.d. |
Tgfb2 | Transforming growth factor, beta 2 | NM_009367 | 1 | 3.0 | n.d. | n.d. | - | n.d. | n.d. |
Msx1 | Homeobox, msh-like 1 | NM_010835 | 5 | 1.7 | n.d. | n.d. | 2.5 | n.d. | n.d. |
Extracellular matrix related | |||||||||
Mmp14 | Matrix metalloproteinase 14 (membrane-inserted) | NM_008608 | 14 | 4.5 | 5.44 ± 0.57 | 0.0002 | 3.2 | 5.16 ± 0.85 | 0.0028 |
Mmp9 | Matrix metalloproteinase 9 | NM_013599 | 2 | 1.6 | 2.97 ± 0.33 | 0.001 | 1.54 | 1.79 ± 0.28 | 0.092* |
Cd44 | CD44 antigen | NM_009851 | 2 | 2.7 | 7.25 ± 2.73 | 0.0625* | 1.9 | 5.28 ± 1.62 | 0.0409 |
Tgfb1i1 (Hic5) | Transforming growth factor beta 1 induced transcript 1 | NM_009365 | 7 | 2.8 | 7.39 ± 2.54 | 0.046 | 2.1 | 6.26 ± 1.95 | 0.0357 |
Gastrulation markers | |||||||||
Gsc | Goosecoid homeobox | NM_010351 | 12 | - | n.d. | n.d. | 15 | 7.11 ± 0.79 | < 0.0001 |
Fgf8 | Fibroblast growth factor 8 | NM_010205 | 19 | 2.0 | n.d. | n.d. | 14.1 | 13.85 ± 2.58 | 0.0006 |
Sp5 | Trans-acting transcription factor 5 | NM_022435 | 2 | 2.4 | n.d. | n.d. | 12 | n.d. | n.d. |
T | Brachyury | NM_009309 | 17 | 2.3 | n.d. | n.d. | 10.6 | 60.7 ± 8.43 | 0.0004 |
Lhx1 | LIM homeobox protein 1 | NM_008498 | 11 | - | n.d. | n.d. | 10.6 | n.d. | n.d. |
MixL1 | Mix1 homeobox-like 1 | NM_013729 | 1 | - | n.d. | n.d. | 6 | 13.98 ± 2.93 | 0.0046 |
En1 | Engrailed 1 | NM_010133 | 1 | 1.6 | n.d. | n.d. | 4.95 | n.d. | n.d. |
Wnt8a | Wingless-related MMTV integration site 8A | NM_009290 | 18 | - | n.d. | n.d. | 4.4 | n.d. | n.d. |
Sox9 | SRY-box containing gene 9 | NM_011448 | 11 | - | n.d. | n.d. | 3.5 | n.d. | n.d. |
Fgf17 | Fibroblast growth factor 17 | NM_008004 | 14 | 2.5 | n.d. | n.d. | 2.4 | n.d. | n.d. |
Wnt9a | Wingless-type MMTV integration site 9A | NM_139298 | 11 | 2.4 | n.d. | n.d. | - | n.d. | n.d. |
Eomes | Eomesodermin | NM_010136 | 9 | - | n.d. | n.d. | 2.1 | 8.03 ± 0.67 | < 0.0001 |
Chrd | Chordin | NM_009893 | 16 | - | n.d. | n.d. | 1.97 | n.d. | n.d. |
Cer1 | Cerberus 1 homolog | NM_009887 | 4 | - | n.d. | n.d. | 1.91 | n.d. | n.d. |
Foxa2 | Forkhead box A2 | NM_010446 | 2 | - | n.d. | n.d. | 1.8 | 8.98 ± 2.55 | 0.0216 |
Fgf5 | Fibroblast growth factor 5 | NM_010203 | 5 | - | n.d. | n.d. | 2.16 | 3.16 ± 0.14 | < 0.0001 |
Igf2 | Insulin-like growth factor 2 | NM_010514 | 7 | 3.3 | 3.9 ± 0.72 | 0.0078 | 1.7 | n.d. | n.d. |