Figure 5From: Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse developmentMature Smad4 mutant embryoid bodies display a thickened endoderm and expanded basement membrane. The day 10 Smad4 null EBs strongly express Dab2. The thick extracellular matrix, detectable by hematoxylin and eosin (H&E) staining, stains positive for both laminin and collagenIV.Back to article page