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Table 3 KEGG analysis on gene lists for Foxl2-null or Wnt4-null fetal ovaries.

From: Foxl2functions in sex determination and histogenesis throughout mouse ovary development

 

Foxl2null-depleted

Foxl2null-enriched

 

Pathway

N

Proportion

N

Proportion

p-value

   Ubiquitin mediated proteolysis

(42)

(0,06)

11

0,02

0,00003

   Insulin signaling pathway

(35)

(0,05)

8

0,01

0,00004

   ErbB signaling pathway

(28)

(0,04)

6

0,01

0,00018

   MAPK signaling pathway

(58)

(0,09)

26

0,04

0,00067

   Axon guidance

(40)

(0,06)

15

0,02

0,00132

   Prostate cancer

(22)

(0,03)

5

0,01

0,00146

   Colorectal cancer

(27)

(0,04)

8

0,01

0,00179

   Long-term potentiation

(19)

(0,03)

4

0,01

0,00252

   Adherens junction

(24)

(0,04)

7

0,01

0,0032

   Glioma

(19)

(0,03)

5

0,01

0,00644

   Apoptosis

(15)

(0,02)

3

0,00

0,0074

   Wnt signaling pathway

(41)

(0,06)

19

0,03

0,00773

   Alanine and aspartate metabolism

0

0,00

(8)

(0,01)

0,00318

   One carbon pool by folate

2

0,00

(13)

(0,02)

0,00333

   Glyoxylate and dicarboxylate metabolism

0

0,00

(9)

(0,01)

0,00154

   Glycolysis/Gluconeogenesis

3

0,00

(19)

(0,03)

0,00035

   Oxidative phosphorylation

7

0,01

(33)

(0,05)

0,00001

   Ribosome (protein synthesis)

3

0,00

(79)

(0,13)

0

 

Wnt4 null-depleted

Wnt4 null-enriched

 

Pathway

N

Proportion

N

Proportion

p-value

   Ribosome (protein synthesis)

(55)

(0,09)

7

0,01

0

   Oxidative phosphorylation

(51)

(0,08)

7

0,01

0

   Glycolysis/Gluconeogenesis

(18)

(0,03)

3

0,00

0,00008

   Fructose and mannose metabolism

(15)

(0,02)

4

0,01

0,00194

   Calcium signaling pathway

16

0,03

(45)

(0,06)

0,00548

   Neuroactive ligand-receptor interaction

19

0,03

(52)

(0,07)

0,00441

   Leukocyte transendothelial migration

9

0,01

(33)

(0,04)

0,00396

   Cell adhesion molecules (CAMs)

7

0,01

(31)

(0,04)

0,00141

   Cytokine-cytokine receptor interaction

18

0,03

(54)

(0,07)

0,00135

   Natural killer cell mediated cytotoxicity

9

0,01

(36)

(0,05)

0,00115

   Complement and coagulation cascades

2

0,00

(19)

(0,02)

0,00131

   ECM-receptor interaction

9

0,01

(37)

(0,05)

0,00076

   Focal adhesion

23

0,04

(70)

(0,09)

0,00014

  1. Columns from left to right: name of the pathway, number and proportion of genes that are down- or up-regulated in the respective knockout model, and corresponding p-value. All the pathways with FDR < 10% are shown. Underlines indicate pathways that are enriched in the corresponding columns.