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Figure 6 | BMC Developmental Biology

Figure 6

From: Tbx1 and Brn4regulate retinoic acid metabolic genes during cochlear morphogenesis

Figure 6

Cyp26c1 expression is reduced in Brn4-; Tbx1+/- embryos. Transverse sections through the cochlear duct (c) probed for Cyp26c1 (A-C, E-F) or Tbx1 (D) in Tbx1+/-, Brn4- and Brn4-;Tbx1+/- embryos at E12.5. Cyp26c1 expression is reduced in the ventromedial POM surrounding the cochlear duct of Brn4-;Tbx1+/- embryos (C and F) compared to Tbx1+/- (A) and Brn4- (B and E) embryos. Tbx1 is expressed in this same region (D) and overlaps with Cyp26c1 expression. Expression of Cyp26c1 in the otic epithelium is unaffected in Brn4-;Tbx1+/- embryos. Scale bar is 200 μm.

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