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Figure 3 | BMC Developmental Biology

Figure 3

From: Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

Figure 3

Skeletogenesis is severely impaired in Col2a1- Cre ; Apc15lox/15lox embryos. (A-E) Greatly impaired skeletal development and growth arrest of Col2a1-Cre;Apc15lox/15lox embryos. Gross appearance (A-C) and Alcian blue and Alizarin red staining (D-E) of skeletal preparations of Col2a1-Cre;Apc15lox/15lox embryos and control littermates at indicated developmental stages. Conditional Apc mutants showed lack of mandible outgrowth (arrowheads), poor limb development (black arrows), and an open thoracic and abdominal cavity (red arrows). Scale bars: 1 mm.

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BMC Developmental Biology

ISSN: 1471-213X

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