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Figure 1 | BMC Developmental Biology

Figure 1

From: Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development

Figure 1

The embryonic period (4–8 weeks): CAIX expression was first seen in the cytotrophoblasts (A, arrow) and certain cells in the embryo (B), such as primitive mesenchyma (B1 long arrow), external surface of the embryo (B2, short double arrows), and mesenchymal cells of the chorion (B2, double long arrows). In the later embryonic stage, CAIX expression was primarily observed in the mesencyhmal cells involving chondrogenesis, as shown in the facial bone (C), bronchial tree (D), the limb (E), and the pelvic bone (F). All of the epithelial cells lining the body cavity were also positive for CAIX, e.g. the peritoneum (F), and the surface of the gonad (G). The only CAIX-positive cells in the CNS are ependymal cells (H). Original magnifications: A, B and H (20×); B1 and B2 (40×); C, D and F (4×); E and G (10×).

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