Figure 3

Body weight, pancreas weight, fasting blood glucose, ductal area, β cell area and islet cell ratios are unaffected in RIP-RacN17 mice. (A,B) Quantification of body and pancreas weight of six months old female mice showed no difference between transgenic and wild-type littermates (n = 3). (C) Fasting blood glucose levels in 7–9 month old mice (7 Wt male + 11 Tg male) showed no differences between transgenic and wild-type littermates. (D) Measurements of the percentage of pancreas area occupied by DBA-labelled ducts on frozen sections of eight to nine weeks old mice showed no difference between transgenic and wild-type littermates (n = 4). (E) Quantification of β cell area (Ins Area/Ecad Area) in eight to nine weeks old mice showed no difference between transgenic and wild-type littermates (n = 3). (F-H) Measurements of endocrine cell area ratios in eight to nine weeks old mice showed no difference between insulin and glucagon (Glu Area/Ins Area) (F), insulin and somatostain (Som Area/Ins Area) (G) or insulin and pancreatic polypeptide (PP Area/Ins Area) (H) (n = 3). Error bars represent standard deviation from the mean (± s.d.).