Figure 1

Transgenic constructs with mutations of WW binding sites at the Dystroglycan C-terminal end. Schematic drawing of pUASp constructs with mutations in different WW binding sites. FL – construct which encodes full length Dg, 2WW – constructs with mutations in both WW binding sites, PPSG – mutation in the N-terminal WW binding motif WWbsII PPSY → PPSG. C1 – deletion of the proline-rich C-terminus.