Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints

Table 1 Table 1

Mouse Genotype^a	Embryo/Adult Number	H19		Snurf/Snrpn
		Percentage Methylated CpGs
		Mat	Pat	Mat	Pat
Dnmt1^+/+		3	93	91	0
Dnmt1^Δ1o/+		3	57^d	44^d	1
TgEL/+		2	92^b	92^b	4
	Embryo 1	9	88^b	89^c	4
	Embryo 2	13	69^c	79^b	4
	Embryo 3	8	87^b	73^b	1
Dnmt1^Δ1o/+, TgEL/+	Embryo 4	0	54^c	84^b	2
	Adult 1	0	71^b	93^b	3
	Adult 2	1	87^b	77^b	11
	Adult 3	17	85^b	93^b	5
	Adult 4	11	82^b	96^b	0

^a Dnmt1^Δ1o/+embryo is from a cross between a Dnmt1^Δ1o/Δ1ofemale mouse and a Cast-7 male; Dnmt1^Δ1o/+, TgEL embryo is from a cross between a Dnmt1^Δ1o/Δ1o, TgEL female mouse and a Cast-7 male.
^b No significant difference compared to Dnmt1^+/+ methylation
^c Significant difference compared to Dnmt1^+/+ methylation (p < 0.05)
^d Significant difference compared to Dnmt1^+/+ methylation p < 0.025)

ISSN: 1471-213X