Table 1 Summary of transgenic mice used to study Cryaa expression in lens.
From: Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivates
Constructs | Regulatory Elements | Copy Number Range | Onset of Expression | Expression Location |
|---|---|---|---|---|
αA-BAC 4 lines* | 148 kb BAC | 2–3 | E10.5 (3/3) | Lens (epithelium and fiber cells) |
αA-BAC(ΔDCR3) 3 lines | 148 kb BAC-DCR3 (with 1 kb deletion) | 2–5 | E10.5 (1/3) | Lens (epithelium and fiber cells) |
Cryaa (15 kb) 6 lines/analyzed 4 | 15 kb Cryaa (-DCR3) | 5–15 | E10.5 (4/4) | Lens (epithelium and fiber cells) Brain |