Figure 10
From: Expression of Groucho/TLE proteins during pancreas development
A model of the proposed role of the Gro/TLE factors in cell fate choices during endocrine pancreas development. A schematic depicting a cross-repressive model of the genetic network regulating α-, β-, and ε-cell fate is shown based on our experimental data, as well as evidence from the literature on pancreas development [3, 47] and on models of neuronal cell specification.