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Figure 5 | BMC Developmental Biology

Figure 5

From: Targeted disruption of the mouse Csrp2gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure

Figure 5

Structure of the Z discs from wild-type, Csrp 2-/-, and Csrp3/Mlp-/- mice. (A) The structures of Z discs from wild-type, Csrp2-/-, and Csrp3/Mlp-/- were displayed by immunofluorescence microscopy using an antibody directed against sarcomeric α-actinin. The space bar represents 10 μM.(B) Heart sections of wild-type mice (WT) and Csrp2 nulls (Csrp2-/-) were infiltrated with an expoxy resin and examined in a Philips TEM 400 transmission microscope. The intercalated discs are each marked by arrowheads. Note the moderate and pronounced convolution of the membrane at the intercalated disc of Csrp2 null compared to wild type mice. (Original magnification × 9.000). (C) Heart sections of wild-type mice (WT) and Csrp2 nulls (Csrp2-/-) at higher magnification (× 18.000). For electron microscopic analysis three hearts taken from each genotype were analysed. The most representative images are shown in (B) and (C).

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