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Figure 6 | BMC Developmental Biology

Figure 6

From: Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice

Figure 6

Confocal images of transverse sections through the pelvic region at the level of the pelvic plexus primordium of E11.5 TH-GFP mice processed for Hu (blue), GFP (TH, green) and either GFRα1 (red) (A-D), GFRα2 (red) (E-H) or TrkC (red) (I-L) immunohistochemistry. Chains of Hu+ cells were present in the pelvic plexus primordium (A, E, I). A sub-population of the Hu+ cells was also GFP+ (TH+) (A-B, E-F, I-J). GFRα1 immunoreactivity was present on Hu+/TH-negative neurons, as well as some TH+/Hu+ neurons and some cells in the clusters that were TH-/Hu- (arrows) (A-D). Weak GFRα2 immunostaining was found on all Hu+ cells in the pelvic plexus primordium; however, strong GFRα2 immunoreactivity was found on many of the Hu+/TH+ cells (asterisks), whereas GFRα2 immunorectivity was weak on the Hu+/TH-negative sub-population (E-H). TrkC immunostaining was mainly observed on the Hu+/TH+ sub-population (I-L). Scale bars = 20 μm.

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