Figure 3From: Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn miceInverted fluorescence micrographs of embryonic day (E) 11.5 pelvic plexus explants grown on collagen gels impregnated with various neurotrophic factors (A-D'). After 4 days, the explants were processed for Tuj-1 (A, B, C, D) and TH (A', B', C', D') imunohistochemistry. There was limited Tuj-1+ (A) and TH+ (A') fibre outgrowth from control gels. GDNF-impregnated gels produced significant Tuj-1+ (B) and TH+ (B') fibre outgrowth; whereas Neurturin treated gels only produced significant Tuj-1+ fibre outgrowth (C), with little TH+-fibre outgrowth (C'). The level of outgrowth from NT-3-impregnated gels was not significant (D-D'). Scale bar = 500 μmBack to article page