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Figure 3 | BMC Developmental Biology

Figure 3

From: Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice

Figure 3

Inverted fluorescence micrographs of embryonic day (E) 11.5 pelvic plexus explants grown on collagen gels impregnated with various neurotrophic factors (A-D'). After 4 days, the explants were processed for Tuj-1 (A, B, C, D) and TH (A', B', C', D') imunohistochemistry. There was limited Tuj-1+ (A) and TH+ (A') fibre outgrowth from control gels. GDNF-impregnated gels produced significant Tuj-1+ (B) and TH+ (B') fibre outgrowth; whereas Neurturin treated gels only produced significant Tuj-1+ fibre outgrowth (C), with little TH+-fibre outgrowth (C'). The level of outgrowth from NT-3-impregnated gels was not significant (D-D'). Scale bar = 500 μm

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