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Figure 1 | BMC Developmental Biology

Figure 1

From: Control of cell cycle entry and exiting from the second mitotic wave in the Drosophiladeveloping eye

Figure 1

Cyclin E/Cdk2 activity is required for S phase in SMW and is sufficient to induce S phase in Su(H) mutant cells. (A-C) BrdU (red) incorporation is blocked in Minute+cdk2 mutant cells in the SMW. (D-F) In Minute+cdk2 mutant cells Cyclin E level (red) is up-regulated. (G-I) In Su(H) mutant cells, BrdU (red) is not incorporated in the SMW. (J-L) Su(H) mutant cells have high level of Cyclin E protein (red). Mutant clones were marked by the absence of GFP (A-L). In all discs, anterior is to the left. White arrowheads in these and subsequent figures indicate the position of the SMW. The over-expression of Cyclin E (M) or Cdk2 (N) alone is not able to induce ectopic BrdU incorporation (red) in Su(H) mutant clones. (O) Simultaneous over-expression of Cyclin E and Cdk2 induces large number of BrdU incorporation in Su(H) mutant cells. MARCM clones were marked by the GFP (M-O).

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