Figure 1From: GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart developmentAlternative splicing isoforms of Lhx9. A. Splicing isoforms of the mouse Lhx9 gene as predicted by the NCBI and Ensembl databases and (B) the proteins they encode. (I). Transcript variant 3 (NM_001042577; ENSMUST00000112026) encodes for a 397 amino acid (aa) long protein with intact homeodomain (HD); (II). Transcript variant 1 (NM_001025565; ENSMUST00000019374) encodes for a 330aa protein LHX9α with a truncated HD and a different C terminus; (III) Transcript variant 2 (NM_010714; ENSMUST00000112030) is the uncharacterized transcript and would encode for a 321aa protein LHX9β that has a different N-terminus in addition to a truncated HD. Black boxes represent coding exons; white boxes show untranslated regions; blue and purple filled boxes represent LIM domains 1 and 2; red fill shows HD; the sizes for all exons (bps) are shown for each isoform. The Ensembl annotation predicts much longer 3'-untranslated regions for transcripts 1 (II) and 2 (III); these, however, were not detected previously [30] and could not be confirmed by us experimentally or by a BLASTN search against the EST database (not shown).Back to article page