Figure 3

Effect of Noggin over-expression on regeneration outcome following amputation at the future knee or ankle level. Histogram of limb regeneration success as defined by the number of toes regenerated by stage 58 following amputation at either the future knee or ankle level of the limb bud at stage 52. WT and N1 animals were both subjected to heat shocks that activate transgene expression of Noggin in N1s. Non heat shocked controls were amputated at knee level. Error bars represent standard error and significant differences between WT and N1 animals are denoted by **).