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Table 1 Embryos with mutant genotype Tie2·Cre+/-Srff/fdie by E14.5

From: Endothelial-specific ablation of Serum Response Factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality

Age

Cre+/Srff/f

Cre+/Srff/+

Cre-/Srff/f

Cre-/Srff/+

E9.5

7 (0)

5

10

16

E10.5

12 (0)

14 (1)

15

26

E11.5

19 (1)

29 (2)

7

17

E12.5

24 (11)

21

17

7

E13.5

21 (19)

15

14 (2)

16

E14.5

10 (8)

3

3

4

E18.5

2 (2)

4

2

5

Neonate

0

18

20

13

  1. Genotypic analysis of mouse embryos generated by crossing Tie2Cre+/-Srff/+ male mice with Srff/ffemale mice. Numbers represent total embryos of each genotype; numbers in parentheses indicate mutant phenotype and grossly necrotic embryos. The conditional loss of Srf gene function in endothelial cells resulted in embryonic death by E14.5; no animals with mutant genotype were detected during late gestational age or at birth.