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Figure 5 | BMC Developmental Biology

Figure 5

From: Endothelial-specific ablation of Serum Response Factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality

Figure 5

Yolk sac tissues of Tie2Cre+/-Srff/fembryos display vascular disintegration and blood pooling. Photographs of whole unfixed, unstained intact yolk sacs containing mouse embryos at E12.5 (A, B, C, D) and E13.5 (E, F). Yolk sac tissues from mutant embryos showed disorganized vascular networks at E12.5 (B) that become more pronounced at E13.5 (D, F arrowheads). Blood pools (B, asterisks) were also observed in mutant yolk sac tissues.

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