Figure 4
Tie2Cre+/-Srff/fembryos exhibit yolk sac vascular failure. Photographs of whole unfixed, unstained intact yolk sacs containing mouse embryos at E10.5 (A, B), E11.5 (C, D), E12.5 (E, F) and E13.5 (G, H). Embryos with Tie2Cre+/-Srff/fgenotype exhibited severely disrupted vascular networks at E12.5 (F) and E13.5 (H) as compared to wild-type littermates (E and G respectively). Labelled boxes in Fig. 4 correspond to images in Fig. 5.