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Figure 1 | BMC Developmental Biology

Figure 1

From: Endothelial-specific ablation of Serum Response Factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality

Figure 1

Tie2Cre+/-Srff/fembryos exhibit internal hemorrhaging. Photographs of whole unfixed, unstained mouse embryos at E10.5 (A, B), E11.5 (C, D), E12.5 (E, F) and E13.5 (G, H). Tie2Cre+/-Srff/fmutant embryos (B, D, F, H) exhibited internal hemorrhaging compared to wild-type littermates (A, C, E, G). This effect progressed with increasing gestational age. E14.5 mutant embryos were grossly necrotic and unsuitable for analysis. Labelled boxes in Fig. 1 correspond to images in Fig. 2.; Lv = liver. Arrowhead marks minimal hemorrhaging observed in E11.5 embryos.

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