Figure 3

Pups suckled by Src knockout mice have dramatically reduced weight gain. Graphs demonstrating the weight gain of pups foster nursed by Src-/- mice compared to the weight gain of pups nursed by control dams. Litters were normalized to eight pups. N = 3 for the control mice and error bars depict the s.e.m. in the growth of these control litters. The start of each graph represents day 1 of lactation (first day post-partum) for the nursing mother. The weights of pups nursed by Src-/- mice were recorded for 9 days. A) Weight gain of a single litter of eight newborn FVB pups fostered by Src-/- mouse in comparison to three litters of FVB pups nursed by FVB dams. B) Weight gain of a single litter of eight C57Bl6 pups that were 8 days old when they were cross-fostered onto a Src-/- mouse that was one day post-partum. The growth rate is compared to three litters of C57Bl6 pups nursed by control C57Bl6 dams. C) Weight gain by a single litter of 6-day old Src+/- pups cross-fostered onto a Src-/- mouse that was one day post-partum in comparison to three litters nursed by Src+/- dams.