Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance

Table 3

genotype	Distribution of RGCs projecting ipsilaterally from each retinal quadrant (expressed as % of total projection to thalamus)				% of ipsilateral projection originating from vt retina
	dn	dt	vn	vt
Pax6 ^Sey/+	0.53 ± 0.26	0.23 ± 0.01	0.40 ± 0.20	1.44 ± 0.72	44 ± 25
Pax6 ^+/+	0.22 ± 0.06	0.39 ± 0.12	0.33 ± 0.17	1.16 ± 0.47	45 ± 10
PAX77 ⁺	1.03 ± 0.46	1.59 ± 0.42	1.27 ± 0.43	4.01 ± 2.32	34 ± 11
PAX77 ^+/+	1.24 ± 0.71	2.30 ± 1.57	0	5.84 ± 2.70	44 ± 18

Distributions of RGCs projecting ipsialterally to the thalamus in Pax6^Sey/+, Pax6^+/+, PAX77⁺, and PAX77^+/+ embryos in the four retinal quadrants. Note that in all genotypes the ipsilaterally projecting RGCs are enriched in the ventrotemporal (vt) quadrant (shown in bold) compared to the dorsonasal (dn), ventronasal (vn), and dorsotemporal (dt) quadrants regardless of the overall size of the ipsilateral projection (shown in Fig 8 B,C). All values mean ± s.e.m. Sample sizes: Pax6^Sey/+n = 4; Pax6^+/+ n = 9; PAX77⁺ n = 5; PAX77^+/+ n = 4.

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