Figure 7
Inhibition of the FGF pathway by SU5402 does not show any similarities to U0126-treated embryos. A-C: Expression of the Fgf-pathway target gene sef is downregulated in SU5402 (C) but not in U0126-treated (B) embryos. D-I: Expression of the notochordal marker genes col2a1 (D-F) and shh (G-I) also show different defects in SU5402 and U0126-treated embryos. J-M: Expression of lox1 (J, K) and lox5b (L-M) is not decreased normally by U0126-treatment. N, O: copa mRNA persists and is not downregulated by U0126-treatment.