Figure 2

Bmp5^clvmutation causes more severe skeletal defects than a Bmp5 null ( Bmp5^null) mutation. Alizarin red-stained bones of 12-week +/+, Bmp5^null/Bmp5^null, and Bmp5^clv/Bmp5^clvmice show the following: (a) shortening of the greater horn (gh) and lesser horn (lh) of the hyoid bone and decreased calcification of the thyroid cartilage (tc), (b) absence of anterior tubercles (at) and thinning of the neural arch (na) of the 6th cervical vertebra, (c) reduction of the sesamoid (s) and nearly complete loss of the deltoid tuberosity (dt) of the humerus, (d) absence of the spinous process (sp) of the 2nd thoracic vertebra, (e) absence of the transverse process (tp) and anapophysis (a) of the 3rd lumbar vertebra, and (f) abnormal fusion of posterior sternal segments and loss of the xiphoid process (x) at the end of the sternum in Bmp5^clv/Bmp5^clvmice.